Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Preparation and evaluation of microemulsion of vinpocetine. Preparation and evaluation of microemulsion containing antihypertensive drug article pdf available in international journal of applied pharmaceutics 105. Optimization of microemulsion formulations with linker molecules.
Preparation and evaluation of microemulsionbased transdermal. Electrophoretic method faster micro electrophoresis apparatus. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion. The irritation study showed that optimized microemulsion was a safe transdermal delivery system. Preparation and evaluation of a microemulsion for oral. Electrical conductivity measurement is a tool for the evaluation stability shortly after preparation. Preparation and evaluation of nanoemulsion formulation by using spontaneous emulsification deepa dhiman, amit kumar pal, aman mittal, sunit saini department of pharmacy, smt. Basic aspects of microemulsion microemulsion are fluid, transparent, thermodynamically stable oil and water system and stabilized by a surfactant usually in conjunction with cosurfactant.
Preparation and evaluation of novel microemulsion based hydrogels for dermal delivery of benzocaine. Surfactantfree microemulsion composed of oleic acid, n. Herein, we report a surfactant free microemulsion denoted as sfme, consisting of oleic acid oil phase, water, and npropanol without the amphiphilic molecular structure of a traditional surfactant. This article is from jundishapur journal of natural pharmaceutical products, volume 8. Finally the physicochemical properties of the optimized microemulsion including ph, viscosity, refractive index, conductivity and particle size distribution were examined, which showed stable behavior after more than 12 months at ambient temperature. Preparation and evaluation of aceclofenac topical microemulsion. Formulation and evaluation of microemulsionbased hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. In the case of our experiment, oily dats was selected as the oil phase of ow microemulsion. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999. May 04, 2004 read preparation of nimodipineloaded microemulsion for intranasal delivery and evaluation on the targeting efficiency to the brain, international journal of pharmaceutics on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The main objective of the present investigation was to develop and evaluate the potential of microemulsion me for the ocular delivery of vanocomycin vm.
Preparation and evaluation of microemulsion systems containing. The aim of the present study was to design novel drug delivery system containing ramipril microemulsion. Preparation and evaluation of microemulsion systems. Preparation of aceclofenac microemulsion aceclofenac was added to the mixtures of oil, surfactant, and cosurfactant with varying ratios as described in table 1, and then an appropriate amount of water was added to the mixture drop by drop with constant stirring on magnetic stirrer. About 50 million people worldwide suffer from epilepsy and nearly two out of every three new cases are reported in developing countries. Microemulsion was prepared using constant ratio of surfactant sco surfactant cos, various combinations of oil and scos were produced. Preparation, optimization and characterization of microemulsions microemulsions are isotropic systems, which are difficult to formulate than ordinary emulsions because their formulation is a highly specific process involving. Preparation and evaluation of microemulsion formulations of naproxen for dermal. The results were compared to the characteristics obtained for the most commonly. Piperine pip is an alkaloid characterized by memoryenhancing properties but challenging oral delivery obstacles. Formulation and characterization of microemulsion system. The objective of investigation is to formulate a microemulsion drug. Preparation and evaluation of microemulsion containing antihypertensive drug. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext.
The drug is be dissolved in the lipophilic part of the microemulsion i. The aim of the present work was applying essential oilbased microemulsions to improve the solubility, ph stability, photostability, and skin permeation of quercetin for. Phase behavior, particle size, viscosity and solubilization. Ena athaide department of biochemistry institute of science,mumbai msc1,sem2 2. Formulation and evaluation of microemulsion based delivery. The pseudoternary phase diagrams for microemulsion regions were constructed using oleic acid as the oil, tween 80 as the surfactant and isopropyl alcohol ipa. Characterization and evaluation of an oral microemulsion. Rajarajan department of pharmaceutics, karnataka college of pharmacy, hegde nagar, bangalore560064, karnataka, india. Preparation and evaluation of fluconazole topical microemulsion article pdf available in journal of pharmacy research 23 january 2009 with 1,206 reads how we measure reads. However, the therapeutic effect of quercetin is limited due to the poor water solubility, ph instability, light instability, and skin permeation. Preparation and evaluation of transnasal microemulsion of. The solid microemulsions of emamectin benzoate with the same content of surfactants were prepared by a selfemulsifying method. The microemulsion was prepared with pharmaceutically acceptable ingredients such as oleic acid, tween 80 and peg400.
Formulation and evaluation of microemulsion based tablets of acyclovir for better patient compliance jatin dedakia, shivprasad h. Preparation and evaluation of nanoemulsion formulation by. The particle size and zeta potential of the microemulsion was evaluated using nano zeta sizer. Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant. During the preparation of microemulsion, ethyl oleate as oil phase, tween 80 as a surfactant, ethanol as. Formulation and evaluation of an alternative triglyceride.
The animals were kept in an agreeable environment with free access to. Preparation and evaluation of cilnidipine microemulsion. Formulation and evaluation of cyclosporin a emulgel for ocular delivery. Design and formulation of optimized microemulsions for dermal. Preparation of standard curve the absorption maxima of drug were determine by uvspectrophotometer and was used for preparation of standard curve in ph 7. Preparation and evaluation of emamectin benzoate solid. Preparation and evaluation of valdecoxib emulgel formulations. Formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam biswajit biswal1, nabin karna 1, jyotiranjan nayak2, vivek joshi 1dept. Preparation and evaluation of ibuprofenloaded microemulsion for improvement of oral bioavailability liandong hu, jianxue yang, wei liu, and li li school of pharmaceutical sciences, hebei university, baoding, 071002, pr china abstract the purpose of the current study was to improve the solubility of ibuprofen, a poorly watersoluble drug, in. Preparation of nimodipineloaded microemulsion for intranasal. Microemulsion polymerization is a complex heterogeneous process where transport of monomers, free radicals and other species such as chain transfer agent, cosurfactant and inhibitors between the aqueous and organic phases, takes place. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. To enhance the solubility and bioavailability of poorly absorbable fexofenadine, microemulsion system composed of oil, surfactant and cosurfactant was developed for intranasal delivery.
Preparation and evaluation of ibuprofenloaded microemulsion. Formulation consideration and characterization of microemulsion. These are selected as recommended by the camag tlc scanner iii manual. The increased incidence of inflammatory diseases has. Generally, a microemulsion consists of oil, water, surfactant, and sometimes cosurfactant. Enhancement of antioxidant and skin moisturizing effects of. Anesthetic evaluation of a novel phospholipidfree 1%. Pdf preparation and evaluation of microemulsion containing. After the addition of each drop, the mixture was stirred and observed. Rahul nair, department of pharmaceutics, sree vidyanikethan college of pharmacy, sree sainath nagar, tirupati, andhra pradesh, india517102. Quercetin can bring many benefits to skin based on its various bioactivities. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34. After each realized experiment for preparation of carbonate microstructures, the two microemulsion phases were separated and each was subjected to quantitative. Pdf optimization of microemulsion formulations with.
Status epilepsy is a serious neurological emergency characterized by severe bouts of seizures. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. A new triglyceride free propofol microemulsion for intravenous injection was formulated using nonionic surfactants, poloxamers and polyethylene glycol 660 hydroxystearate. Doylea nanoemulsions are kinetically stable liquidinliquid dispersions with droplet sizes on the order of 100 nm. Preparation, optimization and characterization of microemulsions 167 5. Full text preparation and evaluation of microemulsionbased. Microemulsion formulation design and evaluation for. Aquino i, gutierrezblanco e, ocampo l, gutierrez l, bernardbernard mj, sumano h.
Nov 21, 2014 the microemulsion definition provided by danielson and lindman in 1981 will be used as the point of reference. Aug 01, 2016 compared with the cosurfactant free microemulsion system, ethanol or glycerol was used as a cosurfactant to replace a certain proportion of surfactant tween 80 and the microemulsion systems were constructed based on the same preparation method. Oral braintargeted microemulsion for enhanced piperine. An me gel base composed of 35% ipm, 20% water, and 45% tween 80. The objective of this study was to develop an oral microemulsion formulation of the antitumor diterpenoid agent, ent11. The drugloaded microemulsion formulation was stable for at least 3 months of storage at 25 c. Pseudoternary phase diagrams were constructed using water titration method at 252c to obtain the appropriate components, and their concentration ranges that resulted in a large existence area of microemulsion were chosen. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate. Mar 14, 2019 formulation and evaluation of oxiconazole emulgel for topical drug delivery author. Yesim karasulu 2017 preparation and evaluation of novel microemulsion based hydrogels for dermal delivery of benzocaine, pharmaceutical development and technology, 22. Pdf preparation and evaluation of microemulsion formulations of. The result showed that the microemulsion is a suitable carrier for catechin topical application. Preparation and evaluation of microemulsion formulations of.
Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. The amount of surfactant and cosurfactant to be added and the percent of oil. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution. Preparation and evaluation of tretinoin microemulsion. Formulation and evaluation of microemulsionbased hydrogel. Propofol possesses several favorable characteristics, including an antiemetic effect and rapid emergence from unconsciousness with minimal residual drowsiness.
In this articles various techniques have been discussed in detail for the preparation of nanoparticles using natural polymers chitosan,alginate and proteins such as albumin,gelatin,legumin. Their small size leads to useful properties such as high surface area per unit volume, robust. Abstract a topical preparation containing aceclofenac was developed using an ow microemulsion system. Anesthetic evaluation of a novel phospholipidfree 1% propofol microemulsion formulation in dogs. Pdf preparation and evaluation of fluconazole topical. Characterization of microemulsions prepared using isopropyl.
Pg as surfactantcosurfactant mixture scos in ratio of 15. Preparation and evaluation of vancomycin microemulsion for. Formulation and evaluation of oxiconazole emulgel for topical drug delivery author. Evaluation of burn wound healing activity of novel fusidic. Majumdar sptm, svkms nmims, shirpur, dhule 425 405, maharashtra, india. The objective of this work was to prepare and evaluate sa me. The phase behavior of the ternary system was investigated, showing that there were a singlephase. The aim of the present study was to design novel ow microemulsion of glimepiride and to study its. Pseudoternary phase diagram was used to define the microemulsion area, and samples from the best combinations, i. Pdf formulation and evaluation of microemulsionbased. Microemulsion formulation which displayed an optical transparency of. The principal aim of this study was to develop an oral microemulsion formulation of berberine in order to improve its bioavailability. An oilfree microemulsion for intravenous delivery of.
Nanoparticles, deacetylation, alginate nanoparticles. Moreover, the microemulsion with and without catechin showed less irritant properties when compared with the standard irritant group. Mandal baroda college of pharmacy, vadodara, india. Evaluation of microemulsion, hydrogel and microemulsion based hydrogel % transmittance, globule size, and zeta potential determination the optimized microemulsion f5 showed 94. The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo. Anesthetic evaluation of a novel phospholipidfree 1% propofol microemulsion formulation in dogs veterinaria mexico oa issn. Preparation and evaluation of novel microemulsion based hydrogels for dermal delivery of benzocaine article pdf available in pharmaceutical development and technology 224. The objective of the present research was to examine the possible usage of microemulsion based gel for fusidic acid fa dermal application as burn wound treatment. Pseudoternary phase diagrams preparation and microemulsion formulation. The aim of this investigation was to evaluate the formulation for storage stability, antimicrobial activity, toxicity and preclinical efficacy. The cbz solution cs meant for comparative evaluation of mmebased systems was prepared. Preparation and evaluation of vancomycin microemulsion for ocular drug delivery authors. In our preliminary test, the best solubilization and microemulsifying. Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid.
The final product developed is a lyophilized amphotericin b, oil and surfactant blend for reconstitution in water to yield a microemulsion containing 5 mgml of the drug. The optimized microemulsion consisted of 1% vinpocetine, 4% oleic acid, 20% cremophor rh40, 10% transcutol p and 65% distilled water ww, in which drug solubility was about 2,100 fold compared to that in water and the apparent permeation rate across the excised rat skin was 15. Pdf preparation and evaluation of novel microemulsion. All formulations were found free from nasal ciliotoxicity and stable for 6. It requires rapid termination of seizure activity because if the episode of epilepsy remains untreated, it may lead to a permanent damage to the brain. Preparation and evaluation of aceclofenac topical microemulsion rohit ramesh shah, chandrakant shripal magdum, shitalkumar shivagonda patil and nilofar shanawaj niakwade appasaheb birnale college of pharmacy, sangli, india. An oil free microemulsion for intravenous delivery of diallyl trisulfide. Preparation and evaluation of tretinoin microemulsion based on pseudoternary phase diagram eskandar moghimipour 1,2, anayatollah salimi 1,2, fatemeh leis 2 1 nanotechnology research center, jundishapur university of medical sciences, ahvaz, iran. The aim of study was to develop a microemulsion based tablets to increase the solubility. Formulation and evaluation of microemulsionbased hydrogel for.
Pharmacodynamic evaluation also indicated lesser intensity of seizures in rats treated with optimized formulation in comparison to rats treated with oral carbamazepine microemulsion and nasal carbamazepine solution which suggested carbamazepine transnasal delivery system as an effective alternate therapy for treatment of epilepsy. Preparation and evaluation of microemulsion formulations. Design and formulation of optimized microemulsions for. Several methods were used since it is recommended to base the conclusions of antioxidant activity on at least two different test methods and the antioxidant activity is dependent on the method used. Formulation and evaluation of microemulsion based topical.